Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazole-2-yl) carbamate) is a broad spectrum benzimidazole anthelmintic. Veterinarians use it to treat gastrointestinal parasites in dogs, cats and rabbits as well as freshwater fish and reptiles.
In three experiments, unirradiated EMT6 tumor-bearing BALB/c mice received either no drug or three daily fenbendazole injections. These injections did not affect tumor growth in either the nonirradiated or irradiated groups.
What is Fenbendazole Capsules?
Fenbendazole (commonly referred to as Panacur) is a benzimidazole-class anthelmintic used to control parasitic infections in livestock and domestic food-animal species. Among these, it is especially useful in the treatment of nematodes and trematodes in commercially raised game birds, such as pheasants. Specifically, two studies have shown that it has more than 90% efficacy against the internal helminth Syngamus trachea in pheasants (1).
The stochastic process used in this model calculates the amount of pheasant tissue with fenbendazole sulfone residues that needs to be consumed daily to observe adverse effects in human consumers, using different FDA liver tolerances and LODs for countries and tissues (Table 2). Moreover, it takes into account the possibility of safe extra-label drug use in pheasants from countries with lower MRLs or LODs. This makes it possible to use a smaller tissue intake when carrying out the pharmacokinetic parameters. It also helps to reduce the risk of false positives in the presence of co-ingestants.
How to Give Fenbendazole Capsules to Your Pet
Fenbendazole is a broad-spectrum benzimidazole anthelmintic that attacks parasites in their internal organs by inhibiting their ability to form microtubules. Microtubules are structural proteins that provide the basis for the cell’s structure and function. This medication kills a wide variety of intestinal parasites, including giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not Dipylidium caninum, the common dog tapeworm), pinworms, aelurostrongylus, and strongyloides. It does not affect heartworms, which are a disease caused by the worm Dirofilaria immitis, and is only partially effective against giardia (although some studies suggest that it may have some activity against experimental giardia infections).
When administered at appropriate doses, fenbendazole is usually well-tolerated. However, components released by the dying parasites can cause reactions in some pets. These include drooling, vomiting, and diarrhea. These symptoms are more likely to occur in pets with very high parasite loads, and in cases where fenbendazole is given at higher-than-regular doses. If these symptoms occur, contact your veterinarian immediately.
Common Side Effects of Fenbendazole Capsules
Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum benzimidazole anthelmintic that is approved for use in many animal species. It has been shown to be very effective as an anthelmintic and has a high safety margin. It also has been found to be extremely effective in inhibiting the growth of cancer cells.
Fenbendazole was shown to interfere with the glucose intake of cancer cells, thus starving them of their main source of energy. This has led to a dramatic decrease in the rate of tumor progression in laboratory settings and in patients that have undergone facility treatment with chemotherapy and radiation.
The anti-tumor effects of fenbendazole are due to its binding to the cellular microtubules. It is known to cause destabilization of the mitosis mechanism in cancer cells, causing them to break apart and die. This is a powerful effect that has the potential to be used in combination with other cancer treatments to increase the effectiveness of those treatments.
Dosage and Administration
Fenbendazole is used to treat intestinal parasites such as roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis), and lungworms (Trichuris suis). In addition, it has been shown to be effective in treating Giardia.
While some research in cells and animals suggests antiparasitic drugs like fenbendazole might also be effective cancer treatments, no such drug has been proven safe or effective for humans yet. A specialist cancer information nurse at Cancer Research UK tells Full Fact that there is insufficient evidence that fenbendazole cures cancer, and the drug has not gone through clinical trials to find out whether it would be safe to use for this purpose.
In laboratory experiments, fenbendazole has been found to reduce tumor growth in mice by inhibiting cell proliferation and causing the death of cancer cells. It has been shown to do this through its ability to disrupt microtubules, stabilize p53, and interfere with glucose metabolism.